pentobarbital will decrease the extent or influence of diazepam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Sturdy or average CYP3A4 inducers might improve level of diazepam elimination; as a result, efficacy of diazepam may be lowered.pentobarbital will lessen the extent or outcome of itraconazole by i